Taking more than 25 mg per day of rofecoxib (Vioxx) is linked to a tripling of the risk of heart attack, said a paper presented in August at the International Society for Pharmacoepidemiology Conference in Bordeaux, France.

Researchers analyzed data from the HMO Kaiser Permanente for all patients prescribed COX-2 inhibitors or non-steroidal anti-inflammatories. Patients on higher doses of rofecoxib increased their heart attack risk by a factor of 3.15. No increase was found in patients taking another COX-2 inhibitor, celecoxib (Celebrex).

Kaiser intends to re-evaluate use of this drug based on this information.

The manufacturer disagreed with the conclusions of the study.

“Observational analysis do not have the rigor of randomized, controlled clinical trials. … Based on the data that are available from our clinical trials, Merck stands behind the efficacy and safety, including cardiovascular safety, of Vioxx,” said Peter S. Kim, PhD, president of Merck Research Laboratories.

We're here to help!

We live by our creed of “helping those who need it most” and have helped thousands of clients get the justice they desperately needed and deserved. If you feel you have a case or just have questions please contact us for a free consultation. There is no risk and no fees unless we win for you.

Fields marked * may be required for submission.

Wonderful to work with

Beasley Allen did a great job with my case. They were wonderful to work with. They were available by phone when I needed them, treated me with the utmost respect and worked hard on my behalf. If a need arises in the future, I would definitely call on them again.