Memorial Sloan Kettering Cancer Center announced it is seeking patients with pleural mesothelioma to participate in a study investigating the highest dose of genetically modified T cells that can be used to treat “patients with pleural mesothelioma that has the protein mesothelin and persists despite prior treatment.”

The treatment involves removing some of the patient’s own T cells (a type of white blood cell) and genetically modifying them in the laboratory to recognize mesothelin, a protein found on the surface of certain types of normal and cancer cells. The modified T cells, known as CAR T cells, are then returned to the patient to “find and kill cancerous cells throughout the body.” The CAR T cells are also designed to counter a protein called PD1, which acts as a “brake” on the immune system so that T cells are better able to target and destroy cancer cells.

The treatment will be administered directly into the chest cavity through a catheter after the patient receives the chemotherapy drug cyclophosphamide.

In order to be eligible for the study, patients must meet the following criteria:

  • Have pleural mesothelioma that persists despite prior treatment;
  • May not have previously received CAR T cells;
  • Must have recovered from the serious side effects of prior therapies;
  • Must be able to walk and do routine activities for more than half of their normal waking hours; and
  • Must be 18 years of age or older.

For more information about the study or to inquire about eligibility, contact the Memorial Sloan Kettering Cancer Center at cart@mskcc.org.

Mesothelioma litigation

Beasley Allen lawyers handle mesothelioma claims. They are looking at cases of industrial, occupational and secondary asbestos exposure resulting in lung cancer or mesothelioma as well as claims of asbestos-related talc products linked to mesothelioma. Charlie Stern in our Toxic Torts Section is the lead attorney working on these types of cases. As an experienced mesothelioma lawyer, Charlie is well equipped to tackle asbestos cases, which are highly complicated and require someone with a true understanding of the facts, medical issues, science and law. He is working together with Will Sutton, an experienced lawyer in our Toxic Torts Section. Contact us for more information.

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