A March 2008 FDA patient safety news bulletin reiterated warnings to healthcare professionals about dangerous and possibly fatal skin reactions to the drug carbamazepine in certain patient populations. Reactions include Stevens Johnson syndrome and toxic epidermal necrolysis.
Stevens-Johnson syndrome is a rare, serious disorder of the skin and mucous membranes. It begins with several days of flu-like symptoms, followed by inflammation of your mucous membranes and a painful red or purplish rash that spreads and blisters, eventually causing the top layer of your skin to die and shed.
Dangerous or even fatal skin reactions (Stevens Johnson syndrome and toxic epidermal necrolysis), that can be caused by carbamazepine therapy, are significantly more common in patients with a particular human leukocyte antigen (HLA) allele, HLA-B*1502.
Stevens Johnson syndrome or related toxic epidermal necrolysis may be caused by carbamazepine therapy, especially in patients of Asian ancestry with a particular HLA allele, according to an FDA safety alert.
Updates safety information to include warnings regarding serious rash, including Stevens-Johnson Syndrome, and hypersensitivity reactions and psychiatric symptoms.
Naples High students are mourning the loss of Troy Goode, a senior who died Thursday night after a reaction to a prescribed medication.
The FDA is notifying healthcare professionals about updates to the warning labels of the prescription drug Provigil.
The afternoon she walked into the office of internist Wayne Meyer, Deborah Kaplan had never felt worse. Hours earlier Kaplan had been sent home from a Maryland emergency room with a diagnosis of chickenpox.
Seven major pharmaceutical companies will conduct two studies, one to look at drug-related liver toxicity and the other aimed at a rare drug-related skin condition called Stevens-Johnson syndrome.
"That pain was like a gun shot." That is how 5-year-old Parth Kulkarni described the pain of burns which covered his body, inside and out.
