What is Propylthiouracil?

Propylthiouracil is used to treat hyperthyroidism due to Graves’ disease.

What are the dangers associated with Propylthiouracil?

On June 4, 2009, the U.S. Food and Drug Administration (FDA) issued an Alert notifying health care professionals of the risk of serious liver injury, including liver failure and death, associated with the use of propylthiouracil in adult and pediatric patients. According to the FDA, reports to the agency’s Adverse Event Reporting System (AERS) suggest an increased risk of hepatotoxicity with propylthiouracil as opposed to methimazole, which is also used to treat Graves’ disease.

According to the FDA, there have been 32 AERS reported cases, including 22 adults and 10 children, of serious liver injury associated with propylthiouracil use. The adult cases resulted in 12 deaths and five liver transplants, while among the pediatric patients, one case resulted in death and six in liver transplants.

The FDA recommends that health care professionals closely monitor patients on propylthiouracil therapy for signs and symptoms of liver injury, especially during the first six months of use. It is also recommended that propylthiouracil not be used in pediatric patients unless the patient is allergic to or intolerant of methimazole, and there are no other treament options.

What can I do?

If you or a loved one has suffered a serious side effect as the result of taking propylthiouracil, you may be entitled to compensation. For a free legal consultation, contact us today!



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