Premarin

posted on:
July 23, 2007

author:
Staff

HRT verdict history. Read More

What is Premarin?

Premarin (conjugated estrogens) manufactured by (Wyeth Pharmaceuticals Inc.) is a synthetic estrogen and a common medication used for hormone replacement therapy (HRT). Premarin, approved by the FDA in 1942, is derived from the urine of pregnant mares. Premarin has been prescribed to millions of women for many decades.

What is Premarin prescribed for?

Doctors prescribed Premarin to reduce moderate to severe symptoms of menopause such as hot flashes, night sweats, vaginal dryness and sleep disturbances yet serious and sometimes life threatening Premarin side effects exist.

Previously it was thought that HRT prevented heart disease and strokes by slowing the development of hardening of the arteries. Several major research studies reported in 2002 and 2003 have shown this is not so.The long-term benefits of HRT have recently been brought into question.The most important result of these research studies has been the confirmation that HRT increases the risk of developing breast cancer and endometrial cancer (cancer of the lining of the womb).

What are the dangers associated with Premarin?

The Women’s Health Initiative (WHI) reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary embolism, and deep vein thrombosis in postmenopausal women during 5 years of treatment with conjugated equine estrogens combined with medroxyprogesterone acetate.

The Women’s Health Initiative Memory Study (WHIMS), a substudy of WHI, reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with conjugated estrogens alone and during four years of treatment with conjugated estrogens combined with medroxyprogesterone acetate. Premarin has also been linked to the following serious side effects: Ovarian Cancer, Lupus, Scleroderma, Gallbladder Cancer.

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